Serum Autotaxin Levels in Cholestasis of Pregnancy

S

Sisli Hamidiye Etfal Training and Research Hospital

Status

Unknown

Conditions

Intrahepatic Cholestasis of Pregnancy

Study type

Observational

Funder types

Other

Identifiers

NCT02480478
518

Details and patient eligibility

About

Intrahepatic cholestasis of pregnancy is the most common liver disease in pregnancy. It is is a pregnancy-specific liver disorder with onset mainly in the third trimester of pregnancy. ICP is characterized by pruritus, elevated serum fasting bile salts and transaminases and an increased risk of adverse fetal outcomes. Serum autotaxin levels were found highly sensitive and specific biomarker to to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. The purpose of the study is to determine the diagnostic accuracy of serum autotaxin activity in cholestasis of pregnancy.

Full description

Collected data will enable us to compare serum autotaxin levels in cholestasis of pregnancy and healthy control group.

Enrollment

50 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Clinical diagnosed cholestasis of pregnancy patients

Exclusion criteria

  • acute or chronic liver disease
  • acute or chronic gallbladder disease

Trial design

50 participants in 2 patient groups

intrahepatic cholestasis of pregnancy
Description:
5 ml whole blood sample is going to collect from intrahepatic cholestasis of pregnancy group for the assessment of serum autotaxin levels
healthy control group
Description:
5 ml of whole blood is going to taken from healthy control group

Trial contacts and locations

0

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Central trial contact

Hakan Erenel, MD,OBGYN

Data sourced from clinicaltrials.gov

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