Serum Biomarker HE4 During IVF Treatment (FHE4)

Turku University Hospital (TYKS)

Status

Unknown

Conditions

Human Epididymal Secretory Protein E4

IVF Treatment

Study type

Observational

Funder types

Other

Identifiers

NCT01576744

FHE4-2010

Details and patient eligibility

About

Human epididymal secretory protein 4 (HE4) is a new biomarker for ovarian cancer. The effect of IVF stimulation will be evaluated in order to see whether severe hormonal changes in the gonadotrophin and steroid status affect the serum levels of this marker. Findings will be compared to serum concentrations of CA-125, which is currently the most often used marker for ovarian cancer.

The intention is to determine the serum concentration of HE4 and CA-125 in serial samples in 20 women undergoing IVF stimulation. Samples will be taken following GnRH agonist suppression, 2-3 times during FSH stimulation, at ovum pick up and two weeks following embryo transfer at the time of the hCG-test. The ovarian follicle count and the serum estradiol concentrations are recorded throughout the treatment. The serum biomarker HE4 is expected to ba a stable marker, which does not respond significantly to hormonal stimulation.

Enrollment

20 patients

Sex

Female

Ages

27 to 39 years old

Volunteers

No Healthy Volunteers

Inclusion criteria