Serum Bupivacaine Concentration Levels After Injection of Liposomal Bupivacaine Into the Knee

Utah System of Higher Education (USHE)

Status: Completed

Conditions: Anesthesia, Local

Treatments: Drug: liposomal bupivacaine/plain bupivacaine peri-articular injection

Study type: Observational

Funder types: Other

Identifiers

NCT02626559

IRB_00082660

Details and patient eligibility

About

Serum levels of bupivacaine over time after peri-articular injection of a mixture of liposomal bupivacaine and plain bupivacaine during total knee arthroplasty.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults of at least 18 years of age having a primary, unilateral total knee arthroplasty with a surgical plan to have an intra-articular injection of a mixture of 266 mg of Exparel, 125 mg of bupivacaine, 1:300,000 epinephrine, and 0.9% saline to make a total volume of 100 ml.

Exclusion criteria

• Known hepatic dysfunction or renal insufficiency (creatinine > 1.5 mg/dL);
• allergy to the study medications;
• pregnancy;
• incarceration;
• inability to communicate with the investigators;
• morbid obesity (body mass index > 40 kg/m2).