Serum CTRP3 and RBP4 Levels in Obesity and Hypertension

Third Military Medical University

Status: Completed

Conditions: Hypertension; Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT02226471

SW1000

Details and patient eligibility

About

Insulin resistance is closely correlated with obesity and cardiovascular disease. Adipokines may play important roles in the pathogenesis of obesity, which are a link between obesity and obesity-related disorders.C1q/TNF-related protein-3 (CTRP3) and retinol-binding protein 4 (RBP4) are novel adipokine that modulates the action of insulin in various diseases. This study addressed the relationship between CTRP3, RBP4 and IR in newly diagnosed obesity and essential hypertension.

Full description

Serum CTRP3 and RBP4, anthropometric and metabolic parameters were determined in 480 newly diagnosed obesity and essential hypertensive patients not taking anti-obese and antihypertensive medications and 66 normal weight (NW) and normotensive subjects. All subjects were divided into two groups depending on body mass index (BMI), including NW group and obesity group, and then four subgroups were divided according to obesity and hypertension, including NW-normal blood pressure subgroup (NW-NBP), NW-hypertension subgroup (NW-HTN), obese-normal blood pressure subgroup (OB-NBP), obese-hypertension subgroup (OB-HTN).

Enrollment: 2,000 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Hypertension not taking antihypertensive medications
2. Obesity not taking anti-obese or lipid-lowering medications

Exclusion criteria

1. Heart failure;
2. pregnant or lactating
3. diabetes
4. thyroid disease
5. fractures
6. osteoporosis
7. tumors;

Trial design

2,000 participants in 4 patient groups

NW-NBP group

Description:

normal weight and blood pressure subjects

NW-HTN group

Description:

Normal weight with hypertension subjects

OB-NBP group

Description:

obese-normal blood pressure subjects

OB-HTN group

Description:

Obese-hypertension subjects