Serum CXCL10 and CRP Levels in Patients with Acne Vulgaris in Correlation with Disease Severity

Assiut University

Status: Not yet enrolling

Conditions: Acne Vulgaris

Treatments: Diagnostic Test: serum crp; Diagnostic Test: serum cxcl10

Study type: Observational

Funder types: Other

Identifiers

NCT06869109

role of CXCL10 and CRP in acne

Details and patient eligibility

About

the correlations between CXCL10 levels, CRP, and acne severity scores (e.g., Global Acne Grading System) suggest that CXCL10 could serve as a biomarker of inflammation and acne severity. Understanding the relationship between CXCL10, CRP, and acne severity may offer insights into novel therapeutic strategies targeting inflammatory pathways in acne.

Full description

Cross-sectional Observational Study. using 4 groups a 3 of different acne severity and controle one . the serum cxcl10 and crp will measured in each patient to correlate with disease severity

Enrollment: 88 estimated patients

Sex: All

Ages: 12 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients aged 12-40 years diagnosed with acne vulgaris.
2. Both genders included.
3. Patients with mild, moderate, or severe acne severity as determined by a validated scoring system (e.g., Global Acne Grading System).
4. Patients not on systemic acne treatment (e.g., isotretinoin or antibiotics) or anti-inflammatory drugs.

Exclusion criteria

1. Patients with autoimmune diseases, systemic illnesses, acute infection or any other chronic inflammatory conditions that may affect CRP or CXCL10 levels.
2. Pregnant or lactating individuals.

Trial design

88 participants in 4 patient groups

mild acne group

Description:

mild disease severity

Treatment:

Diagnostic Test: serum cxcl10

Diagnostic Test: serum crp

moderate acne group

Description:

moderate disease severity

Treatment:

Diagnostic Test: serum cxcl10

Diagnostic Test: serum crp

severe acne group

Description:

severe disease severity

Treatment:

Diagnostic Test: serum cxcl10

Diagnostic Test: serum crp

control group

Description:

healthy people

Treatment:

Diagnostic Test: serum cxcl10

Diagnostic Test: serum crp