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Serum CXCL10 and CRP Levels in Patients with Acne Vulgaris in Correlation with Disease Severity

A

Assiut University

Status

Not yet enrolling

Conditions

Acne Vulgaris

Treatments

Diagnostic Test: serum crp
Diagnostic Test: serum cxcl10

Study type

Observational

Funder types

Other

Identifiers

NCT06869109
role of CXCL10 and CRP in acne

Details and patient eligibility

About

the correlations between CXCL10 levels, CRP, and acne severity scores (e.g., Global Acne Grading System) suggest that CXCL10 could serve as a biomarker of inflammation and acne severity. Understanding the relationship between CXCL10, CRP, and acne severity may offer insights into novel therapeutic strategies targeting inflammatory pathways in acne.

Full description

Cross-sectional Observational Study. using 4 groups a 3 of different acne severity and controle one . the serum cxcl10 and crp will measured in each patient to correlate with disease severity

Enrollment

88 estimated patients

Sex

All

Ages

12 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Patients aged 12-40 years diagnosed with acne vulgaris.
  2. Both genders included.
  3. Patients with mild, moderate, or severe acne severity as determined by a validated scoring system (e.g., Global Acne Grading System).
  4. Patients not on systemic acne treatment (e.g., isotretinoin or antibiotics) or anti-inflammatory drugs.

Exclusion criteria

  1. Patients with autoimmune diseases, systemic illnesses, acute infection or any other chronic inflammatory conditions that may affect CRP or CXCL10 levels.
  2. Pregnant or lactating individuals.

Trial design

88 participants in 4 patient groups

mild acne group
Description:
mild disease severity
Treatment:
Diagnostic Test: serum cxcl10
Diagnostic Test: serum crp
moderate acne group
Description:
moderate disease severity
Treatment:
Diagnostic Test: serum cxcl10
Diagnostic Test: serum crp
severe acne group
Description:
severe disease severity
Treatment:
Diagnostic Test: serum cxcl10
Diagnostic Test: serum crp
control group
Description:
healthy people
Treatment:
Diagnostic Test: serum cxcl10
Diagnostic Test: serum crp

Trial contacts and locations

1

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Central trial contact

Dina Essam, physician

Data sourced from clinicaltrials.gov

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