Serum Dickkopf-4 as a Biomarker for the Diagnosis and Treatment of Gastrointestinal Stromal Tumor

Shanghai Jiao Tong University

Status: Unknown

Conditions: Gastrointestinal Stromal Tumor

Treatments: Procedure: surgery or biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT02931981

GIST-DKK4

Details and patient eligibility

About

Our study aims to evaluate the role of Dickkopf-4 as biomarkers in the treatment of gastrointestinal stromal tumor.

Full description

To identify whether Dickkopf-4 (DKK4) could be a potential biomarker for diagnosis and prognosis in patients with gastrointestinal stromal tumor (GIST). Serum was collected from 50 patients with GIST. Serological levels of DKK4 were examined by enzyme-linked immunosorbent assay (ELISA). The sensitivity and specificity was compared with modified NIH risk criteria. A 3-year follow-up was monitored to evaluate the correlation between DKK4 serum levels and relapse-free or overall survival. The expression of DKK4 in GIST tumor tissues was also evaluated using immunohistochemistry staining.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary gastrointestinal stromal tumor confirmed pathologically by surgery or biopsy
• Age from 18 - 70 years
• No serious organic and mental illness;

Exclusion criteria

• Pregnancy
• No pathologic result
• Suffering other malignancies at the same time.