Serum Endotoxin Assay to Predict the Development of Postoperative Infectious Complications and Systemic Inflammatory Response Following Percutaneous Nephrolithotomy.

University of Miami

Status: Enrolling

Conditions: Urosepsis; Nephrolithiasis

Study type: Observational

Funder types: Other

Identifiers

NCT04669886

20200234

Details and patient eligibility

About

The aim of the study is to establish an infectious risk stratification system based on pre-and post-operative blood endotoxin profile.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults that is able to consent (≥ 18 years of age)
• Scheduled to undergo PCNL at Uhealth tower and Jackson Memorial Hospitals
• not currently immunosuppressed [White blood count (WBC) >= 2, not on immunosuppressive medications]

Exclusion criteria

• unable to consent and < 18 years of age
• currently immunosuppressed (WBC < 2, not on immunosuppressive medications)

Trial design

150 participants in 1 patient group

endotoxin study group

Description:

Patients scheduled for Percutaneous Nephrolithotomy (PCNL) as surgical treatment for their kidney stones will be evaluated for postoperative endotoxin levels as a risk marker for sepsis.