Serum Folic Acid Status, Genotyping MTHFR 677C-->T, Plasma Homocysteine, DNA Methylation of IGF2 Gene and Microbiota of the Children: Mother-Children Cohort Study

University of Indonesia (UI)

Status: Completed

Conditions: Folic Acid Deficiency

Study type: Observational

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT04096521

0420/UN2.F1/ETIK/2018

Details and patient eligibility

About

This study is part of the East Jakarta Cohort Study to assess the current micronutrient status of the mothers and their children. The study also includes the assessment of genotyping of MTHFR 677C-->T of the mother and DNA methylation of IGF2 gene of the children.

Full description

The initial study recruited 315 mothers in the public health centre and one district hospital in East Jakarta. The follow-up study is able to re-visit the 127 of them. This also includes 127 peers of the subject that lives in the same neighbourhood. The design of the study is case-cohort design, part study of the existing cohort. The assessment of the follow-up study includes the mother and the children born in the initial study. Anthropometric measurement, socioeconomic data from a structured questionnaire, biomarker assessment, blood pressure were obtained from the subjects.

Enrollment: 254 patients

Sex: All

Ages: 3 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• participant in the previous study
• apparently healthy
• data complete
• voluntarily to participate

Exclusion criteria

• not complete data
• migrate
• refuse to participate in the study

Trial design

254 participants in 1 patient group

East Jakarta Cohort Study

Description:

One group included in the study was originated from mothers who participated in the first data collection pregnancy. The follow-up study included mothers and their children born as the subject in the follow-up in the study. This study also includes peer of the subjects that lived in the same neighbourhood since the first cohort study and have children in the same age with cohort participant