Serum Free Amino Acid Concentrations in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy (CRRT)

Medical University of Gdansk

Status: Completed

Conditions: Amino Acid Catabolism Disorder; Sepsis

Treatments: Diagnostic Test: Blood sample analysis

Study type: Observational

Funder types: Other

Identifiers

NCT05739604

NKBBN/575/2019

Details and patient eligibility

About

Sepsis is a life-threatening condition associated with high morbidity and mortality. The breakdown of proteins mainly from skeletal muscles leads to the release of free amino acids (FAAs). The serum FAA pool has been repeatedly assessed and found to be significantly altered in patients with sepsis/septic shock. Sepsis is well known to be the most common factor contributing to the development of acute kidney injury in critically ill patients.

The investigators want to establish the baseline profile of FAAs and their derivatives in patients with sepsis/septic shock undergoing continuous renal replacement therapy due to sepsis-associated acute kidney injury. Secondly, the investigators want to compare the FAA profiles of the survivors and nonsurvivors.

Enrollment: 26 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• over 18 years of age
• present AKI
• requiring renal replacement therapy
• hospitalized at the ICU.

Exclusion criteria

• acute kidney disease requiring renal replacement therapy prior to admission to the ICU
• chronic kidney disease requiring renal replacement therapy prior to admission to the ICU
• history of past CRRT.

Trial design

26 participants in 2 patient groups

Survivors

Description:

Patients hospitalized in the Department of Anaesthesiology and Intensive Care with sepsis or septic shock, undergoing continuous renal replacement therapy due to acute kidney injury, in whom the outcome of treatment was survival.

Treatment:

Diagnostic Test: Blood sample analysis

Nonsurvivors

Description:

Patients hospitalized in the Department of Anaesthesiology and Intensive Care with sepsis or septic shock, undergoing continuous renal replacement therapy due to acute kidney injury, in whom the outcome of treatment was fatal.

Treatment:

Diagnostic Test: Blood sample analysis