Serum Free Fatty Acid Metabolite Biomarkers of Lung Cancer

NeuroTherapia, Inc.

Status: Completed

Conditions: Fatty Acids; Biomarkers; Lung Cancer

Treatments: Other: serum sample

Study type: Observational

Funder types: Other

Identifiers

NCT01692951

12-306

Details and patient eligibility

About

This study aims to evaluate the performance of serum free fatty acids as biomarkers for the identification of lung cancer.

Full description

We will compare the concentration of free fatty acids and their metabolites between patients with lung cancer and control pulmonary patients without known cancer. The diagnostic accuracy will be assessed for potential predictors.

Enrollment: 220 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 40 to 80
• Lung adenocarcinoma with pathological diagnosis
• Lung squamous cell carcinoma with pathological diagnosis
• Control patients should have at least one of the following criteria: (1) current or ex-smoker with at least a 10 pack-year history, (2) a first-degree relative with a history of lung cancer, or (3) a clinical diagnosis of COPD.

Exclusion criteria

• Lung cancer patient without serum sample before the initiation of treatment

Trial design

220 participants in 4 patient groups

Lung adenocarcinoma patients

Description:

Serum samples were collected from patients with lung cancer at the time of their diagnosis, prior to the initiation of treatment. Diagnosis of lung adenocarcinoma was based on pathologic analysis.

Treatment:

Other: serum sample

Control matched to adenocarcinoma

Description:

Control subjects without known cancer and aged from 40 to 75 years should meet at least one of the following criteria: (1) current or ex-smoker with at least a 10 pack-year history, (2) a first-degree relative with a history of lung cancer, or (3) a clinical diagnosis of COPD.

Treatment:

Other: serum sample

Lung squamous cell carcinoma patients

Description:

Serum samples were collected from patients with lung cancer at the time of their diagnosis, prior to the initiation of treatment. Diagnosis of lung squamous cell carcinoma was based on pathologic analysis.

Treatment:

Other: serum sample

Control matched to squamous cell

Description:

Control subjects without known cancer and aged from 40 to 75 years should meet at least one of the following criteria: (1) current or ex-smoker with at least a 10 pack-year history, (2) a first-degree relative with a history of lung cancer, or (3) a clinical diagnosis of COPD.

Treatment:

Other: serum sample