Serum GPER-1 and Oxidant/Antioxidant Levels on Retinopathy in Diabetic Patients

Kahramanmaraş Sütçü İmam University (KSU)

Status

Completed

Conditions

Hormones

Diabetes Mellitus

Diabetic Retinopathy

Treatments

Diagnostic Test: The effect of GPER-1 on the formation of diabetic retinopathy

Study type

Observational

Funder types

Other

Identifiers

NCT04930224

(Project no: 2019/5-24 M

Details and patient eligibility

About

Observational, comparative, cross-sectional study

Full description

This study was conducted on G protein-mediated estrogen receptor 1 (GPER-1), which is thought to be effective in preventing the development of diabetic retinopathy (DR). There are studies proving that GPER-1 prevents neuroprotective effects and vascular pathology in many tissues. In the study, serum GPER-1 and oxidative stress biomarker levels were compared in diabetic patients and healthy control groups. GPER-1 was found to be significantly increased in diabetic patients. In addition, a positive correlation was found with oxidant markers. This may lead to new treatment models in the future.

Enrollment

120 patients

Sex

All

Ages

35 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

40 individuals were required to have Proliferative Diabetic Retinopathy (PDR);
40 were required to have Non-PDR;
40 were required to be healthy, without any systemic disease.

Exclusion criteria

Glaucoma,
Ocular trauma sequelae,
Pathological myopia,
Non-diabetic retinopathy,
A history of previous ocular surgery,
Endocrine disorders (e.g.,thyroidopathy, adrenal gland disorders, pituitary pathologies),
Opacities interfering with fundus examination (e.g., corneal opacity, lens opacity, vitreous cloudiness other than diabetic haemorrhage).