Serum Histone Succinylation as a Novel Prognostic Biomarker in Hematological Malignancies (succinylation)

The First Affiliated Hospital of Xinxiang Medical College

Status: Not yet enrolling

Conditions: Lymphoma; Leukemia

Treatments: Other: This is observational studies, participants are not assigned an intervention as part of the study.

Study type: Observational

Funder types: Other

Identifiers

NCT07131449

chase018 (Other Identifier)

Details and patient eligibility

About

4. Study Population 4.1 Inclusion Criteria Case group

1)≥ 18 years old , regardless of gender; 2)Hematological malignancies confirmed by cytology, histology , or molecular biology , who require subsequent anti-tumor treatment ( chemotherapy , hematopoietic stem cell transplantation, radiotherapy, or cellular immunotherapy ) ; control group

1. ≥ 18 years old , regardless of gender;
2. Non-cancer patients undergoing health checkups;

4.2 Exclusion criteria

1. Pregnant women
2. Those with severe mental disorders or language communication barriers
3. Other circumstances that the researcher judges to be unsuitable for participation in this study The control group was the same as the case group V. Research Design 5.1 Overall Design This study was a single-center prospective case-control study. 5.2 Research Design Process 5.2.1 Study the specific implementation process 1. Phase 1: Screening population for enrollment i. Conduct ethical review and clinical research plan review for the project; ii. 200 patients with hematological malignancies will be selected , basic information collected , and informed consent signed ; iii: 200 healthy subjects are planned to be selected and basic information collected; 2. Second stage: Collect blood samples and perform serum histone succinylation test Blood samples were collected from all 200 eligible participants and 200 healthy subjects for serum histone succinylation testing ; 3. The third stage: statistical analysis of screening results i. Evaluate the differences in serum histone succinylation between patients with hematological malignancies and healthy controls to validate its value in early screening.

ii. Statistical analysis of the correlation between serum histone succinylation and tumor efficacy (including chemotherapy , hematopoietic stem cell transplantation, cellular immunotherapy ) and clinical outcomes . ( Efficacy evaluation was performed using RECIST 1.1 criteria )

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria tumor group

1. ≥ 18 years old , regardless of gender;
2. Hematological malignancies confirmed by cytology, histology , or molecular biology (such as leukemia, lymphoma, multiple myeloma, etc.), who require subsequent anti-tumor treatment ( chemotherapy , hematopoietic stem cell transplantation, radiotherapy, or cellular immunotherapy ) ; control group

1)≥ 18 years old , regardless of gender; 2)Non-cancer patients undergoing health checkups;

Exclusion criteria

1. Pregnant women
2. Those with severe mental disorders or language communication barriers
3. Other circumstances that the researcher judges to be unsuitable for participation in this study

Trial design

200 participants in 1 patient group

Patient Cohort: 200 patients diagnosed with hematological malignancies

Description:

Control Cohort: 200 healthy volunteers

Treatment:

Other: This is observational studies, participants are not assigned an intervention as part of the study.