Serum Hs-CRP in Periodontitis Patients With or Without Diabetes

Cairo University (CU)

Status: Completed

Conditions: Diabetes Mellitus, Type 2; Periodontal Disease

Treatments: Procedure: Scaling and root planing

Study type: Interventional

Funder types: Other

Identifiers

NCT03908606

1281976

Details and patient eligibility

About

the aim of this study was to assess serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal therapy.

Full description

Periodontitis and diabetes are chronic disorders with a two-way correlation as they can both stimulate an inflammatory response with subsequent formation of inflammatory mediators and cytokines. C reactive protein is an inflammatory plasma marker having a role in the systemic reaction to inflammation. thus, our aim in the current study was to evaluate serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal therapy. A total of 60 patients were enrolled in this study. ELISA was used for determination of hs- CRP. Non- surgical periodontal therapy was carried out for all periodontitis patients.

Enrollment: 60 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Diabetic patients type 2
2. Periodontitis patients

Exclusion criteria

1. Smokers
2. Pregnant females

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

Periodontitis patients with diabetes type 2

Experimental group

Description:

scaling and root planing was administered to all patients. Serum samples were collected before and after treatment to assess hs-CRP levels. Glycated hemoglobin was measured before and after treatment

Treatment:

Procedure: Scaling and root planing

Periodontitis patients

Experimental group

Description:

scaling and root planing will be done to periodontitis patients. Serum samples were collected before and after treatment to assess hs-CRP levels.

Treatment:

Procedure: Scaling and root planing

Healthy control group

No Intervention group

Description:

We measured serum levels of hs-CRP in all healthy control subjects