Serum Hyperbilirubinemia as an Early Predictive Factor for Complicated Appendicitis: Single Center Experience

Minia University

Status: Completed

Conditions: Appendicitis, Surgery

Treatments: Procedure: Appendectomy

Study type: Observational

Funder types: Other

Identifiers

NCT07291882

Serum Hyperbilirubinemia

Details and patient eligibility

About

Serum total bilirubin provides a practical guide to early assessment of suspected appendicitis, supporting faster and more proportionate decisions-earlier escalation when overall risk is high and safe observation when it is low. Because testing is rapid, inexpensive, and universally available, integration into local diagnostic pathways is feasible.

Enrollment: 400 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients presented with right iliac fossa pain diagnosed clinically as acute appendicitis and had undergone appendectomy

Exclusion criteria

• patients with past history of jaundice
• patients with history of hyperbilirubinemia hemolytic disease
• positive hepatitis viruses
• cholelithiasis
• acquired or congenital biliary disease
• cancer of the hepatobiliary system

Trial design

400 participants in 2 patient groups

Simple appendicitis ( group A)

Description:

Patients where no perforation, gangrene, or other complications were found during surgery.

Treatment:

Procedure: Appendectomy

Complicated appendicitis (group B)

Description:

• Complicated appendicitis group (B): Patients who presented with perforation or gangrene, confirmed via operative findings and histopathological examination. Total bilirubin levels was measured preoperatively as part of the routine laboratory workup.

Treatment:

Procedure: Appendectomy