Serum IGF-II and Cancer: Can IGF II Levels be Used to Monitor and Screen Patients Specifically for Cervical Cancer

Onconix

Status: Unknown

Conditions: Cervical Intraepithelial Neoplasia III; Cervical Intraepithelial Neoplasia II; Cervical Cancer

Study type: Observational

Funder types: Industry

Identifiers

NCT01371695

onc11-03-164

Details and patient eligibility

About

The purpose of this study is to determine whether Insulin-like Growth Factor II is elevated sufficiently to detect Cervical Intraepithelial Neoplasia II (CIN II), Cervical Intraepithelial Neoplasia III (CIN III), and cervical cancer.

Enrollment: 60 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 - 75 years
• Female
• Normal medical history
• Medical history of a single type of cancer confirmed by biopsy or equivalent criteria
• Squamous cell carcinoma of organs other than cervix
• Adenocarcinoma
• Medical history of inflammatory disease
• May be pregnant
• Pap smear positive for Cervical Intraepithelial Neoplasia II or III
• Squamous cell cervical cancer confirmed by biopsy
• Informed consent
• Willingness to submit a blood sample by venipuncture
• Willingness to submit a second blood sample if necessary

Exclusion criteria

• Age < 18 or > 75 years
• Medical history of cancer other than cervical cancer, Non-islet-cell tumor hypoglycemia, Growth hormone deficiency, Acromegaly, Hepatoma, inflammatory disease in addition to confirmed CIN and cervical cancer