Serum Immunologic Markers Levels in During the Delivery (DIMDOED)

Brno University Hospital

Status: Completed

Conditions: Immunologic Markers

Treatments: Diagnostic Test: Blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT03664999

KDAR FN Brno 2018/9

Details and patient eligibility

About

This study aim to describe dynamics of immunologic markers C1 inhibitor, C3, C4 during the delivery in order to improve early diagnostics of obstetric emergencies, especially with immune etiology.

Full description

Our prospective observational study will explore the differences between dynamics of the complement components C1 inhibitor, C1 inhibitor activity, C3, C4 during the labour in a group of women with physiologic pregnancy and in a group with a risk of complications (pre-eclampsia, HELLP syndrome, placenta praevia, placental abruption, IUGR, previous post partum hypotony).

We will focus on women undergoing the Caesarean delivery. We will also measure D vitamin levels and ACE levels and search for some contexts.

Enrollment: 57 patients

Sex: Female

Ages: 15 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pregnant women undergoing the Caesarean delivery
• Signed informed consent

Exclusion criteria

• Previous hepatitis or other hepatocyte damage

Trial design

57 participants in 2 patient groups

Parturients physiologic pregnancy

Description:

Parturients undergoing caesarean delivery with physiologic pregnancy

Treatment:

Diagnostic Test: Blood sampling

Parturients with risk pregnancy

Description:

Parturients undergoing caesarean with risk of complications (pre-eclampsia, HELLP syndrom, placenta praevia, placental abruption, IUGR, previous post partum hypotony).

Treatment:

Diagnostic Test: Blood sampling