Serum Interleukin 6 in Chronic Obstructive Pulmonary Disease

Beni-Suef University

Status: Completed

Conditions: Chronic Obstr Lung Disease

Treatments: Diagnostic Test: interleukin 6

Study type: Interventional

Funder types: Other

Identifiers

NCT05214508

faculty of medicine

Details and patient eligibility

About

The aim of this study is to estimate level of IL 6 in COPD patients and its relation to COPD severity and acute exacerbation.

Full description

1. A detailed clinical history was be carried out for every patient. In the clinical history, duration of COPD with a history of exacerbation and treatment will be elicited. History of the presence of risk factors such as smoking, exposure to fumes (biomass), and the presence of any other chronic disease were be inquired.
2. Thereafter, the detailed physical examination also had been carried out.
3. Pulmonary function test was performed by master screen NO : 781040 (care fusion) Measurements were obtained for FVC,FEV1,Ratio between them, PEF,FEF25%,FEF50% ,and FEF75% (The readings for FEV1 and Ratio were the ones included in the statistical analysis as indices for obstructive pattern of respiration).
4. Labs including Complete blood count, urea, and serum creatinine ,ESR was done for all patients
5. Exercise capacity by six minutes' walk test.
6. Dyspnea score by MMRC score.
7. Health state assessment by CAT score

3- 8- Determination of IL 6 serum levels. by sandwich enzyme-linked immunosorbent assay (ELISA). The detection range (0.2 ng/L- 8ng/L)

Enrollment: 90 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. All patients aged >40 years and <80 years, of both gender
2. Diagnosed to have COPD according to GOLD 2019 by spirometry
3. Given the consent for participation in the study

Exclusion criteria

1- Any patient with systemic inflammation as

1. Bronchial asthma,
2. rheumatoid arthritis.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 2 patient groups

COPD patient

Active Comparator group

Description:

COPD patients diagnosed based on spirometry, PFT and history

Treatment:

Diagnostic Test: interleukin 6

Control

No Intervention group

Description:

Healthy volunteers