Serum Lactate in Acute Mesenteric Ischemia

Universidad del Rosario

Status: Completed

Conditions: Mesenteric Ischemia

Treatments: Diagnostic Test: Lactate Dehydrogenase

Study type: Observational

Funder types: Other

Identifiers

NCT04671979

DVO005-1-431-CEI969

Details and patient eligibility

About

Background: Acute mesenteric ischemia is a vascular emergency with high mortality because of ambiguous symptomatology and a lack of early diagnostic markers. Lactate dehydrogenase has been described as a mortality biomarker and bowel necrosis length too. Nevertheless, the association between them has been mildly studied. Our objective was to evaluate the association between serum lactate admission levels, bowel necrosis extension, and mortality. Additionally, we performed a mortality characterization.

Materials and Methods: A retrospective cross-sectional study was designed. We reviewed patients' clinical records with acute mesenteric ischemia that attended a hospital between 2012 and 2018. We compared serum lactate admission levels with bowel necrosis length and mortality. A receiver operating characteristic curve was performed on the last association. As post hoc analysis, a classification and regression tree on mortality was fitted.

Enrollment: 74 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Older than 18 years of age
• Required urgent laparotomy with a postoperative diagnosis of acute mesenteric ischemia
• Attended the private academic hospital, between 2012 and 2018
• Had a registered serum lactate dehydrogenase at admission

Exclusion criteria

• Secondary causes of AMI
• Chronic intestinal ischemic
• Patient records with no description of the serum lactate dehydrogenase or extension of intestinal necrosis