Serum Magnesium and Vascular Calcification

Mahidol University

Status: Completed

Conditions: Chronic Kidney Disease; Vascular Calcification

Study type: Observational

Funder types: Other

Identifiers

NCT01293786

03-02-2011

Details and patient eligibility

About

Both Kidney transplantation (KT) and Chronic Kidney Disease (CKD) patients have reduced kidney function. Low serum magnesium is more prevalent in KT recipients. The present study examines the difference in vascular calcification between KT and CKD and its association with serum magnesium.

Full description

Kidney transplantation (KT) improved quality of life and longevity of CKD patients. Nevertheless, kidney function deteriorates overtime in a manner not different from CKD counterparts. Hypomagnesemia is prevalent in KT recipients secondary to immunosuppressive therapy. In addition to serum calcium, phosphate and elemental calcium intake, the relationship between low serum magnesium and vascular calcification (VC) has been observed in small studies in CKD. Whether low serum magnesium associates with VC in KT has never been elucidated. The present study compares vascular calcification between KT and CKD and its association with serum magnesium.

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• kidney transplant recipients at least 1 year post surgery
• predialysis chronic kidney disease with serum creatinine > 1.1 mg/dL in female and 1.3 mg/dL in male

Exclusion criteria

• acute kidney injury
• parathyroidectomy

Trial design

400 participants in 2 patient groups

Kidney transplant recipients

Chronic kidney disease