Serum Nesfatin-1 and Human Cartilage Glycoprotein-39 Levels in Knee Osteoarthritis

Kayseri City Hospital

Status: Completed

Conditions: Degenerative Osteoarthritis; Osteoarthritis of Knee

Treatments: Behavioral: exercise; Biological: intraarticular knee PRP injections

Study type: Interventional

Funder types: Other

Identifiers

NCT06254976

health sciences university

Details and patient eligibility

About

In this study, our objective was to assess the correlation between serum human cartilage glycoprotein-39 (YKL-40) and nesfatin-1 values, the patient's clinical condition, ultrasonographic cartilage thickness measurements, and the response to PRP treatment in knee osteoarthritis (OA)

Full description

The objective of this study is to assess the correlation between serum human cartilage glycoprotein-39 (YKL-40) and nesfatin-1 values, clinical condition, ultrasonographic cartilage thickness measurements, and response to PRP treatment in Knee Osteoarthritis (OA).

Thirty patients diagnosed with grade 2 and 3 knee osteoarthritis (OA) according to American College of Rheumatology (ACR) diagnostic criteria, and scheduled for leukocyte-poor platelet-rich plasma (LP-PRP) injections, were enrolled in the study. Patients were assessed at three time points: before treatment (day 0), after exercise treatment (day 14), and after two doses of LP-PRP treatment combined with exercise treatment once a week (day 28). The evaluation included the Numeric Rating Scale (NRS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), cartilage thickness measurement by ultrasonography (USG), 6-minute walk test (6MWT) parameters, and measurements of serum YKL-40 and nesfatin-1 levels.

Enrollment: 30 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Having patient consent,
• Having stage 2-3 knee osteoarthritis according to the Kellgren-Lawrence scale,
• Being diagnosed with knee osteoarthritis according to ACR (American college of Rheumatology),
• Being over the age of 18 - under the age of 75,
• Having NRS 4 and above

Exclusion criteria

• Those who have had knee surgery before,
• Those who have had any local injections such as physical therapy, intra-articular steroid or hyaluronic acid injection in the knee area in the last 3 months,
• Malignancies,
• Those with local infection, wound, scar in the relevant area,
• Infections, Hepatitis, Immunosuppression,
• Inflammatory arthropathies,
• Uncontrolled Hypertension, uncontrolled Diabetes Mellitus, decompensated heart failure, coronary artery disease, asthma
• Recent trauma,
• Epileptic patients,
• Pregnant women,
• Corticosteroid use,
• Avascular necrosis
• Anemia, bleeding coagulation disorder

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Sequential Assignment

Masking: Single Blind

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30 participants in 2 patient groups

2 week home exercise program

Active Comparator group

Description:

Joint range of motion exercises, four-way straight leg raises, isotonic quadriceps strengthening, hamstring and quadriceps stretching exercises were given. The exercise program was demonstrated by the same physiotherapist. The patients' exercise compliance was questioned and noted.

Treatment:

Behavioral: exercise

2 doses of intraarticular PRP application, 1 week apart

Active Comparator group

Description:

2 doses of intra-articular 3 cc LP-PRP were applied to the patients, 1 week apart, from the inferolateral aspect of the patella, in accordance with antisepsis conditions, by a physical medicine and rehabilitation specialist.

Treatment:

Biological: intraarticular knee PRP injections