Serum Neuroglobin and Nogo-A Concentrations in Acute Traumatic Brain Injury

Shanghai Jiao Tong University

Status: Completed

Conditions: Traumatic Brain Injury

Study type: Observational

Funder types: Other

Identifiers

NCT02229643

658346

Details and patient eligibility

About

Neuroglobin has been described as a marker of traumatic brain injury. Nogo-A plays an important role in mediating neuroanatomical plasticity and functional recovery following traumatic brain injury. The investigators sought to examine the changes in serum neuroglobin and Nogo-A concentrations in patients with traumatic brain injury during the initial 96-h posttraumatic period and assessed the relation of neuroglobin and Nogo-A to Glasgow Coma Score and prognosis of such patients with traumatic brain injury.

Enrollment: 34 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who suffered head trauma and whose highest abbreviated injury score (AIS) was 3 or less (other than head injury)
• Patients who delivered to hospital within 4 h

Exclusion criteria

• Patients who suffered open injuries
• Patients who had existing prior neurological disease
• Patients whose serial serum samples could not be obtained
• Patients less than 18 years of age
• Patients who suffered severe life-threatening injury to organs other than the brain

Trial design

34 participants in 1 patient group

Traumatic brain injury

Description:

Patients delivered within 4 h whose highest abbreviated injury score (AIS) was 3 or less (other than head injury) were considered to be isolated traumatic brain injury cases and were included in this study.