Serum Omentin-1 and Carotid Atherosclerosis In Non-Diabetic Chronic Kidney Disease

Kocaeli Derince Education and Research Hospital

Status: Unknown

Conditions: Non-diabetic Chronic Kidney Disease; Atherosclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT01701830

2012/02

Details and patient eligibility

About

The aim of the study is to evaluate whether a low level of serum omentin-1 is associated with carotid atherosclerosis and mediated by inflammation.

Full description

Atherosclerotic cardiovascular disease is markedly increased in chronic kidney disease. There are a lot of risk factor, along with conventional risk factors. Serum onemtin-1 is a adipokine and suggested as a new marker for vascular disease.It has some anti-atherogenic properties. Studies investigating serum omentin-1 level have usually conducted in patients with diabetes mellitus.

Enrollment: 85 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• between ages of 18 - 65 years old chronic kidney disease of stage 3-4

Exclusion criteria

• Chronic kidney disease of stage 5
• The history of ischemic cardiovascular disease (myocardial infarction, unstable angina, stroke, peripheral artery disease, or cardiovascular revascularization)
• Severe heart failure
• Stage 2 hypertension
• Diabetes mellitus
• Corticosteroid therapy
• Severe hepatic disease
• Smoking
• Inflammatory disease
• Acute infectious disease
• Malignancy

Trial design

85 participants in 2 patient groups

Case Group

Description:

Patients with chronic kidney disease of stage 3-4.

Control group

Description:

30 healthy subject