Serum Parameter Prior and After EUS-guided Fine Needle Aspiration of the Pancreas

Helios Albert-Schweitzer-Klinik Northeim

Status: Unknown

Conditions: Pancreatitis

Treatments: Procedure: blood collection; Procedure: fine needle aspiration

Study type: Observational

Funder types: Other

Identifiers

NCT02397993

Helios 6/1/15

Details and patient eligibility

About

Endoscopic ultrasonography (EUS ) -guided fine needle aspiration (EUS -FNA ) of focal pancreatic lesions is an essential diagnostic procedure with high therapeutic effect in clinical routine.

The aim of this study is to determine the levels of serum lipase, serum amylase and the tumor marker CA 19-9 prior and after EUS-FNA. In animal experiments on dogs, an increase of all three parameters was observed after surgery on the pancreas. For humans, these clinically important data are not yet available .

It is assumed that the probability of pancreatitis with increased activity of lipase and amylase will rise with the number of puncture procedures as well as the size of the puncture needle. In addition, the post-interventional assessment of the tumor marker CA 19-9 could result in a false positive assumption of malignant neoplastic pancreatic lesion.

Enrollment: 208 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• independent indication for pancreatic EUS-FNA
• age ≥ 18 years
• patient able to give informed consent

Exclusion criteria

• Contraindications for EUS-FNA
• pregnancy
• no informed consent available
• known stenosis of esophagus or duodenum
• relevant coagulation disorders

Trial design

208 participants in 1 patient group

FNA, blood collection

Description:

blood collection prior to fine needle aspiration Endoscopic ultrasonography-guided fine needle aspiration of the pancreas blood collection after to fine needle aspiration

Treatment:

Procedure: blood collection

Procedure: blood collection

Procedure: fine needle aspiration