Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy

University Hospital Center (CHU)

Status: Completed

Conditions: Epilepsy

Treatments: Other: blood sampling for drug resistance biomarkers; Device: Magnetic Resonance Imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT01563627

8668

Details and patient eligibility

About

Epilepsy affects 0.7% of the general population and 15-20% of patients develop drug resistance. The temporal lobe epilepsy (TLE) is the most common symptomatic focal epilepsies with a particularly high rate of drug (about 20 to 30%). In this type of epilepsy, where feasible, surgical removal of the home is the best therapeutic outcome.

Mechanisms of epileptogenesis and drug resistance are still mysterious. Of recent clinical and experimental studies have shown that dysfunction of the blood-brain barrier (BBB) contributes to epileptogenesis and drug resistance. It is now recognized that cytokines exacerbate the excitability and permeability of the BBB, which was recently confirmed by studies showing that treatment of inflammation reduces epileptogenesis. Moreover, we have described an association between pathological angiogenesis and BBB permeability in the tissue of patients with excision of drug-resistant TLE. With experimental models, it was revealed an activation of the VEGF-VEGFR2 by seizures leading to rapid degradation of the BBB.

The investigators hypothesis is that the identification of factors involved in BBB permeability may designate potential targets for drug-resistant partial epilepsy.

Enrollment: 70 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with temporal lobe epilepsy (TLE)
• Patient with epilepsy for at least two years. Arm 1: Patient with drug-resistant TLE proved potentially a candidate for surgery.

Arm 2: Patient with TLE seizure-free for 12 months or more

Exclusion criteria

• Patient with a scalable general pathology may lead to increased inflammatory markers: neoplasia, chronic inflammatory diseases etc. ...
• Patient with neurological history other than epilepsy with evolutionary potential or likely to interfere with the inflammatory markers

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

Antiepileptic Drug resistant

Experimental group

Description:

Adult patients suffering from epilepsy drug-resistant and potentially surgical candidates

Treatment:

Device: Magnetic Resonance Imaging

Other: blood sampling for drug resistance biomarkers

Antiepileptic drug Controlled group

Experimental group

Description:

epilepsy well controlled by antiepileptic drugs

Treatment:

Device: Magnetic Resonance Imaging

Other: blood sampling for drug resistance biomarkers