Serum Progesterone Levels on the Day of Frozen Embryo Transfer (FET) and Pregnancy Outcomes (ProFET)

CARE Fertility UK

Status: Completed

Conditions: IVF; Infertility; Infertility, Female

Treatments: Diagnostic Test: Measurement of serum progesterone on the day of FET

Study type: Observational

Funder types: Other

Identifiers

NCT04170517

ProFETStudy

Details and patient eligibility

About

Frozen embryo transfer (FET) cycles have become more common in recent years due to a push towards elective single embryo transfer (SET). While it is known that progesterone supplementation during the luteal phase improves clinical pregnancy rates, there is a paucity of prospective data on the impact of serum progesterone levels on pregnancy outcomes in FET cycles. This multicentre prospective cohort study aims to investigate the association between serum progesterone levels on the day of FET and pregnancy outcomes, and to determine a serum progesterone cut-off value above which clinical pregnancy and live birth are more likely to occur. Women undergoing ART-FET cycles at CARE Fertility clinics in the UK will be recruited and their serum progesterone measured on the day of frozen embryo transfer. Follow-up data will be stored in electronic patient records and analysed to determine whether a low serum progesterone level on the day of FET adversely affects ART outcomes.

Enrollment: 402 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All women undergoing ART with FET.

Exclusion criteria

• None. We aim to study the "every day" patient undergoing FET, and for this we intend to keep the population of the study as unselected as possible.