Serum Proteomic Profiling for the Early Diagnosis of Colorectal Cancer

Fudan University

Status: Completed

Conditions: Colorectal Neoplasms

Treatments: Other: Serum proteomics

Study type: Observational

Funder types: Other

Identifiers

NCT01604798

30973416 (Other Grant/Funding Number)

ZSCG-001

Details and patient eligibility

About

No ideal serum biomarker currently exists for the early diagnosis of colorectal cancer (CRC). Therefore, it is urgent that accurate and reliable serum biomarkers be identified.

Full description

Magnetic bead-based fractionation coupled with matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) was used to screen serum samples from CRC patients and healthy controls.

Enrollment: 547 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Patients with colorectal cancer

Inclusion criteria

• histologically confirmed colorectal cancer
• aged 18 years or older
• have provided written informed consent

Exclusion criteria

• refusal to participate

Healthy controls

Inclusion criteria

• no cancer history
• aged 18 years or older
• have provided written informed consent

Exclusion criteria

• refusal to participate
• have first-degree relative with a known history of colorectal cancer

Trial design

547 participants in 2 patient groups

Colorectal Cancer Patients

Description:

Patients with histologically confirmed colorectal cancer

Treatment:

Other: Serum proteomics

Healthy Controls

Description:

Healthy volunteers

Treatment:

Other: Serum proteomics