Serum Regucalcin Level and Chronic Hepatitis B

Konya Meram State Hospital

Status: Completed

Conditions: Chronic Hepatitis b; Liver Fibrosis

Treatments: Diagnostic Test: Serum regucalcin level

Study type: Interventional

Funder types: Other

Identifiers

NCT05435599

10542 (Registry Identifier)

Details and patient eligibility

About

This study, it was aimed to investigate the relationship between serum regucalcin level and liver fibrosis level in patients with CHB infection.

Full description

Chronic hepatitis B (CHB) infection continues to be an important health problem due to its high morbidity and mortality. For this reason, it is very important to determine the appropriate timing to start antiviral therapy in patients with CHB infection and to evaluate the stage of liver fibrosis in the treatment follow-up. Liver biopsy is the gold standard for detecting liver fibrosis. Although it is generally accepted to be a safe procedure, it can cause some serious complications. For this reason, in recent years, many studies have been conducted on new noninvasive tests in the evaluation of liver fibrosis. One of them is the serum regucalcin level. Studies have shown that serum regucalcin levels increase in liver damage, but there is no study in the literature comparing liver fibrosis and serum regucalcin levels in CHB infection. This study, it was aimed to investigate the relationship between serum regucalcin level and liver fibrosis level in patients with CHB infection.

Enrollment: 120 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being followed up with a diagnosis of chronic hepatitis B
• Not having a known history of liver disease who applied to our outpatient clinic for other reasons
• Having a liver biopsy
• ≥18 years

Exclusion criteria

• <18 years

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Quadruple Blind

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120 participants in 2 patient groups

Chronic Hepatitis B

Other group

Description:

Measurement of serum regucalcin level

Treatment:

Diagnostic Test: Serum regucalcin level

Healthy Volunteers

Other group

Description:

Measurement of serum regucalcin level

Treatment:

Diagnostic Test: Serum regucalcin level