Serum Resistin Level Following Non-surgical Periodontal Therapy in Diabetic Patients With Chronic Periodontitis

Cairo University (CU)

Status

Completed

Conditions

Type2 Diabetes

Treatments

Procedure: non-surgical periodontal therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT04473209

version 1

Details and patient eligibility

About

non-surgical periodontal debridement was performed for diabetic patients with chronic periodontitis as well as for non-diabetic patients but also with chronic periodontitis. Serum resistin level was assessed in the two groups before and after periodontal therapy and also was compared to a healthy control group.

Full description

Background: Resisitin is a recognized marker for chronic inflammatory conditions that could be directly linked with type 2 diabetes mellitus. The aim of this study was to assess serum resistin level in type 2 diabetic patients with chronic periodontitis.

Methods: Forty individuals were recruited in this study and were divided into three groups, diabetic group consisted of 15 diabetic patients (type 2 diabetes mellitus) with moderate to severe chronic periodontitis, non-diabetic group consisted of 15 non-diabetic patients with moderate to severe chronic periodontitis and healthy group consisted of 10 non-diabetic individuals with healthy periodontium. Non-surgical periodontal therapy with supra and subgingival debridement was performed for the diabetic and non-diabetic groups. Pocket depth, clinical attachment level, plaque index, gingival index, serum Resistin and high sensitivity C-Reactive Protein assay were recorded for both groups before and after treatment, while HbA1c was recorded for the diabetic group.

Enrollment

30 patients

Sex

All

Ages

40 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

diagnosed with moderate to severe chronic periodontitis.
Presence of a minimum of 15 natural teeth
Presence of at least four teeth with one or more sites with probing pocket depth (PPD) ≥5mm and clinical attachment level (CAL) ≥4mm
agreement to participate in the study and sign a written informed consent

Exclusion criteria

Patients who received any periodontal treatment or professional scaling and root planing of the teeth for at least 6 months prior to the study initiation
A history of antibiotics therapy and anti-inflammatory drugs within the previous 6 months
Pregnancy or use of contraceptives or any medication related to diabetes
former or current smokers ˂ 5 years.