Serum Serotonin and Pruritus After Intrathecal Morphine in Cesarean Section

Assiut University

Status and phase

Completed

Phase 4

Conditions

Pruritus

Treatments

Drug: Morphine 100 μg

Drug: Morphine 200 μg

Study type

Interventional

Funder types

Other

Identifiers

NCT03209427

17100209

Details and patient eligibility

About

Pruritus is the commonest side effect of intrathecal morphine especially in parturient, but the exact mechanism of pruritus is not clear. Many mechanisms have been suggested. Among these mechanisms is the activation of the 5-HT3 receptors by the intrathecally injected morphine.

Full description

Forty parturients underwent elective cesarean section under spinal anesthesia were divided into two groups of 20 each in this prospective randomized study. Group I received 100 µg of intrathecal morphine (ITM) mixed with 12 mg of 0.5% heavy bupivacaine (M100) while group II received 200 µg of ITM mixed with 12 mg of 0.5% heavy bupivacaine (M200). Two blood samples were taken from each patient for serotonin estimation, preoperatively and 4 hrs later. Postoperatively all patients were assessed for pruritus (incidence & severity), visual analog scale (VAS), first request of analgesia, and total analgesic dose required within 24 hrs.

Enrollment

40 patients

Sex

Female

Ages

18 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

ASA I - II term pregnant patients scheduled for elective cesarean section

Exclusion criteria

patients with a known allergy to the study drugs
significant cardiac, respiratory, renal, neurological, or hepatic disease; -coagulation disorders
BMI > 30 kg/m2
any itchy skin diseases.