Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis

Meenakshi Ammal Dental College and Hospital

Status: Completed

Conditions: Chronic Periodontitis

Treatments: Drug: scaling and root planing along with antibiotic intervention; Procedure: Scaling and root planing

Study type: Interventional

Funder types: Other

Identifiers

NCT03043066

MADC/IRB-IX/2016/193

Details and patient eligibility

About

To compare the effect of non-surgical periodontal therapy with or without systemic administration of amoxicillin and metronidazole on the concentration of serum levels of TRAP-5b in patients with generalized chronic periodontitis.

Full description

30 Chronic periodontitis subjects were divided into two groups- group A underwent scaling and root planing and group B underwent scaling and root planing with systemic administration of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days.

Periodontal parameters probing pocket depth and clinical attachment level were measured at baseline and at 3rd month. Serum TRAP-5b levels were also measured at baseline, 1 month and at 3rd month.

Enrollment: 30 patients

Sex: All

Ages: 30 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Presence of atleast 20 teeth
• more than 30% of sites with clinical attachment loss of ≥ 5 mm
• non-smokers
• no previous history of periodontal therapy

Exclusion criteria

• systemic diseases
• under antibiotics or anti-inflammatory drugs within previous 3 months
• pregnant and lactating women
• allergic to antibiotics

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

Group A -control group

Placebo Comparator group

Description:

15 subjects underwent scaling and root planing

Treatment:

Procedure: Scaling and root planing

Group B-Interventional group

Active Comparator group

Description:

15 subjects underwent scaling and root planing along with antibiotic intervention of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days

Treatment:

Drug: scaling and root planing along with antibiotic intervention