Serum Uromodulin and DN Systematic Review and Meta Analysis

Tanta University

Status: Completed

Conditions: Diabetic Nephropathies

Treatments: Diagnostic Test: The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN; Diagnostic Test: The association of serum uromodulin with DN

Study type: Observational

Funder types: Other

Identifiers

NCT06596863

DKD serum uromodulin

Details and patient eligibility

About

Several studies have investigated the association between the changes of serum uromodulin and diabetic nephropathy (DN). However, the results are still controversial. Hence, this meta-analysis aimed to evaluate the association of uromodulin with DN.

Enrollment: 1,774 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Studies were included if they met the following criteria:

  1. serum level of uromodulin was determined;
  2. the samples were enrolled from diabetic patients;
  3. mean ± SD was reported for uromodulin between patients with and without DN;
  4. the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN was determined

Exclusion criteria

• Studies were excluded according to the following criteria:

  1. duplicate studies;
  2. review articles;
  3. non original research articles;
  4. studies with insufficient data to extract;
  5. non-human research;
  6. studies that determined urine level of uromodulin.

Trial design

1,774 participants in 2 patient groups

Control group

Description:

Included 862 healthy subjects as control group

Treatment:

Diagnostic Test: The association of serum uromodulin with DN

Diagnostic Test: The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

DKD group

Description:

Included 912 patients with DN

Treatment:

Diagnostic Test: The association of serum uromodulin with DN

Diagnostic Test: The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN