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Serum Vitamin D Level and Its Association With Ovarian Reserve and IVF Outcome

F

Fakih IVF Fertility Center

Status

Unknown

Conditions

VITAMIN D Disorders

Treatments

Other: monitor reproductive outcome

Study type

Observational

Funder types

Other

Identifiers

NCT02317718
VitD Study

Details and patient eligibility

About

Vitamin D has a major play in bone and calcium metabolism. Vitamin D deficiency (below 20 ng/ml) has also been linked to adverse health outcomes such as malignancy, cardiovascular disease, immune functioning, and glucose metabolism. Recent data from retrospective and prospective trials have demonstrated contradictive results concerning the role of vitamin D in female reproduction and IVF outcome. Some studies have found that women deficient in vitamin D had lower ovarian reserve and significantly lower clinical pregnancy rates when compared to patients who were sufficient levels in vitamin D. Some studies also demonstrated that serum 25-OH-D3 levels correlates with antimullerian hormone (AMH) levels in women of advanced reproductive age. It may also have a role to play in endocrine dysfunction and abnormal folliculogenesis in polycystic ovaries .

The aim of this prospective cohort study including infertile women undergoing IVF treatment is to investigate the association between serum 25-OH- D3 levels and parametres of ovarian reserve (AMH, antral follicle count, number of oocytes collected) and clinical pregnancy and miscarriage rates .

Full description

Vitamin D has a major play in bone and calcium metabolism. Vitamin D deficiency (below 20 ng/ml) has also been linked to adverse health outcomes such as malignancy, cardiovascular disease, immune functioning, and glucose metabolism. Recent data from retrospective and prospective trials have demonstrated contradictive results concerning the role of vitamin D in female reproduction and IVF outcome. Some studies have found that women deficient in vitamin D had lower ovarian reserve and significantly lower clinical pregnancy rates when compared to patients who were sufficient levels in vitamin D. Some studies also demonstrated that serum 25-OH-D3 levels correlates with antimullerian hormone (AMH) levels in women of advanced reproductive age. It may also have a role to play in endocrine dysfunction and abnormal folliculogenesis in polycystic ovaries .

The aim of this prospective cohort study including infertile women undergoing IVF treatment is to investigate the association between serum 25-OH- D3 levels and parametres of ovarian reserve (AMH, antral follicle count, number of oocytes collected) and clinical pregnancy and miscarriage rates .

Enrollment

500 estimated patients

Sex

Female

Ages

20 to 42 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Subfertile women,
  • Indication for IVF,
  • 20-42 yrs of age.

Exclusion criteria

  • Women on therapeutic supplementation for Vitamin D Deficiency,
  • Recurrent high order implantation failure

Trial design

500 participants in 2 patient groups

Normal vitamin D levels group
Description:
MORE THAN 20 NG/ML VITAMIN D LEVELS
Treatment:
Other: monitor reproductive outcome
Deficient Vitamin D GROUP
Description:
LESS THAN 20 NG/ML LEVELS
Treatment:
Other: monitor reproductive outcome

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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