Setria Performance Blend Supplementation

University of North Carolina (UNC)

Status

Completed

Conditions

Healthy

Treatments

Dietary Supplement: Setria performance blend

Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT04090138

19-1375

Details and patient eligibility

About

The objective of this trial is to evaluate the effects of setria performance blend supplementation on endurance performance in healthy men.

Full description

This study is a randomized, double-blind, placebo-controlled crossover trial in healthy men. Subjects will take either a placebo or setria performance blend (L-citrulline + glutathione) for 8 days. At the day 8, subjects run on the treadmill to measure the time to exhaustion at 90%, 100%, and 110% of peak velocity. Arterial blood flow and blood vessel diameter (via ultrasound), blood analytes (plasma nitrate/nitrite, L-arginine, L-citrulline), subjective feelings of fatigue from a visual analog scale (VAS) and ratings of perceived exertion will be assessed. There is a minimum of a two week washout period in between trials/treatments. The same procedures are completed upon return visit.

Enrollment

25 patients

Sex

Male

Ages

20 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Participant is an adult male between the ages of 20-30 years
Participant is aerobically fit, as defined by a VO2max between 42-70 ml*kg/min (determined by the screening test)
Participant is not obese (18.5 ≦ BMI < 30 kg/m²)
Participant has provided written and dated informed consent to participate in the study
Participant is willing and able to comply with the protocol
Participant is apparently healthy and free from disease, as determined by a health history questionnaire
Participant agrees to refrain from strenuous exercise and alcohol consumption within 24 hours of laboratory visits, and to refrain from caffeine consumption within twelve hours of visits
Participant agrees to refrain from using antibacterial mouthwash, chewing gum, and brushing their teeth on the morning of laboratory visits

Exclusion criteria

Participant has consistently used prescription drugs or ergogenic dietary supplements that may influence study outcomes within eight weeks prior to enrollment, or begins to do so during the study. Potential drugs and supplements include but are not limited to whey protein, creatine, beta-alanine, antihypertensive medications, or anabolic steroids
Participant has gained or lost ≥10 lbs in the previous 2 months
Participant is enrolled in a separate clinical trial involving diet, exercise, physical activity, or the potential ingestion of an active drug or dietary supplement in the previous 2 months and during this study
Participant has participated in a clinical trial within the previous 2 months that includes modifications to their physical and/or diet that may influence study outcomes and during this study
Participant has a known allergy or sensitivity to the placebo or active ingredients
Participant consumes more than 3 alcoholic drinks per day
Participant has used tobacco more than three days per week (on average) in the previous eight weeks
Participant has used recreational drugs within the past month, or refuses to abstain from recreational drug use for the entirety of the study