Severe Head Injury Brain Analysis (SHIBA)

Queen Mary University of London

Status: Completed

Conditions: Brain Injury Traumatic Severe

Treatments: Procedure: Brain biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT05206760

271662

Details and patient eligibility

About

Safety and feasibility study investigating brain biopsy in severe head injury. When a patient undergoes craniotomy or ICP bolt insertion for trauma, a biopsy of brain tissue is taken.

Blood, saliva, urine and faeces samples are also taken for 7 days following the brain biopsy.

CSF is collected if a CSF drainage device is used.

Full description

A minor amendment was submitted to allow histological and immunohistochemical analysis of the samples.

Enrollment: 25 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Severe traumatic brain injury -

Exclusion Criteria: Coagulopathy

Trial design

25 participants in 1 patient group

Trial participants

Description:

Patients with severe traumatic brain injury requiring craniotomy or ICP bolt insertion

Treatment:

Procedure: Brain biopsy