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Severe Leptospirosis in Non-tropical Areas (LEPTOREA)

N

Nantes University Hospital (NUH)

Status

Completed

Conditions

Intensive Care Unit
Leptospirosis
Alveolar Hemorrhage
Epidemiology

Study type

Observational

Funder types

Other

Identifiers

NCT03912506
LEPTOREA

Details and patient eligibility

About

Leptospirosis is a worldwide zoonosis. The mortality of the disease is between 3,6% to 13%, and up to 48% for the severe leptospirosis.

Only few studies exist on severe leptospirosis and none major multicentre on leptospirosis in intensive care units in Europe. The investigators conduct a retrospective multi centric study in metropolitan France in order to identify the characteristic, the treatments and the prognostic factors associated with mortality of sever leptospirosis.

Full description

Leptospirosis is a worldwide zoonosis. The infection is acquired through contact with animal urine on contaminated soil. It is an important remerging infectious disease because of its increasing incidence. Leptospirosis is most common in tropical and rural settings but its incidence has been constantly increasing for the past ten years in Metropolitan France. Most of the cases are asymptomatic or sparsely symptomatic, but some patients develop severe leptospirosis (6% to 59%), requiring hospitalisation in intensive care units. The mortality of the disease is between 3,6% to 13%, and up to 48% for the severe leptospirosis.

Only few studies exist on severe leptospirosis and none major multicentre on leptospirosis in intensive care units in Europe. Therefore, the investigators have decided to carry out this studies. The investigators conduct a retrospective multi centric study in metropolitan France in order to identify the characteristic, the treatments and the prognostic factors associated with mortality of sever leptospirosis.

Enrollment

160 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patient admitted in ICU
  • Leptospirosis confirmed with one laboratory test (MAT, ELISA, PCR, direct examination)

Exclusion criteria

  • No specific exclusion criteria

Trial design

160 participants in 1 patient group

Patient admitted in the ICU for leptospirosis
Description:
Patient admitted in the ICU for leptospirosis None intervention was performed according to retrospective design

Trial contacts and locations

36

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Data sourced from clinicaltrials.gov

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