Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity

Tel Aviv Sourasky Medical Center

Status: Unknown

Conditions: Pregnancy Complications; Intrauterine Fetal Growth Restriction; Preeclampsia; Placental Abruption; Intrauterine Fetal Death

Study type: Observational

Funder types: Other

Identifiers

NCT00573118

FactorVIII

Details and patient eligibility

About

Congenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels.Thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction (IUGR), placental abruption, intrauterine fetal death (IUFD) and repeated pregnancy loss.These severe pregnancy complications are thought to result from thrombotic events occurring in the uteroplacental circulation. Accumulating data have established an association between elevated plasma activity of factor VIII and thrombosis although the mechanism is still not defined and elevated factor VIII activity is now regarded as being equivalent to thrombophilia.

We intend to investigatthe association between factor VIII levels and severe pregnancy complications which are considered to result from placental vascular pathology, i.e., preeclampsia, IUGR, placental abruption and IUFD. We hypothezise that the prevalence of elevated factor 8 will be higher among women with pregnancy complications compared to controls.

Enrollment: 100 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women who had either normal pregnancy or complicated pregnancy.

Exclusion criteria

• Other causes of pregnancy complication such as infections, anomalies and fetal malformations

Trial design

100 participants in 2 patient groups

1

Description:

The study group included 49 patients with a previous history of one or more of the following pregnancy complications: preeclampsia (n = 17), severe IUGR (n = 13), IUFD (n = 14) or placental abruption (n = 5).

2

Description:

The control group included 49 healthy women who delivered during the study period, who did not smoke during pregnancy and in whom pregnancy and delivery were uneventful