Severity of Sarcopenia in Parkinson's Disease

Ankara University

Status

Completed

Conditions

Parkinson Disease

Study type

Observational

Funder types

Other

Identifiers

NCT07014514

E-59394181-604.01-112205

Details and patient eligibility

About

This study aimed to determine the prevalence of sarcopenia and dynapenia in Parkinson's disease patients, classified into early-stage (<2.5) and moderate-stage (≥2.5) according to the Modified Hoehn and Yahr scale, and healthy controls using the ICF-based ISarcoPRM algorithm, and to examine the differences in regional muscle morphology, muscle strength, and physical performance between groups.This study was conducted as a cross-sectional research. The study included 43 Parkinson's disease patients aged 50-75 years, classified as stages 1-3 according to the Modified Hoehn-Yahr Scale, and 22 healthy individuals with similar demographic characteristics. Parkinson's disease patients were divided into two subgroups according to the Modified Hoehn-Yahr Scale: early stage (<2.5) and intermediate stage (≥2.5). Demographic information of all participants was recorded, and clinical evaluations were performed. Parkinson's disease staging was assessed using the Modified Hoehn-Yahr Scale. Muscle mass was assessed using ultrasonography to measure anterior femoral muscle thickness. Muscle strength was measured by handgrip strength, and physical performance was assessed using a five-count sit-up test.

Enrollment

65 patients

Sex

All

Ages

40 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Score between 24 and 30 on the Mini Mental State Examination
Be diagnosed with Parkinson's Disease by a neurologist
Stage 1-3 on the Modified Hoehn and Yahr Scale

Exclusion criteria

Inability to communicate verbally
Elderly people with severe visual impairment, neurological disorders in addition to Parkinson's and/or congestive heart failure
Older adults in whom exercise is not recommended