Sevoflurane and Hyperperfusion Syndrome

Seoul National University

Status

Unknown

Conditions

Moyamoya Disease

Hyperperfusion Syndrome

Treatments

Drug: Sevoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT02510586

Sevo_postconditioning

Details and patient eligibility

About

The aim of the present study is to evaluate the effect of sevoflurane postconditioning on the incidence of postoperative hyperperfusion syndrome following revascularization surgery in moyamoya patients.

Full description

Postoperative hyperperfusion syndrome is a common complication in moyamoya disease patients receiving revascularization surgery. Previously its incidence has been reported to be 17~50%, but little remains regarding frequency of reperfusion injury after revascularization surgery in patients with moyamoya disease. Volatile anesthetics such as sevoflurane has been introduced clinically to reduce reperfusion injury and preconditioning with sevoflurane induced ischemic tolerance like as ischemic preconditioning. However, there was no report on the neuroprotective effect of sevoflurane postconditioning on ischemic/reperfusion injury in human brain. Therefore, We evaluated the neuroprotective effect of sevoflurane postconditioning on the incidence of postoperative hyperperfusion syndrome after revascularization surgery in moyamoya disease patients.

Enrollment

152 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult patients receiving cerebral revascularization surgery due to moyamoya disease

Exclusion criteria

Patients who do not agree to the study
Patients with uncontrolled diabetes or hypertension
Patients using cyclooxygenase2 inhibitor or with previously using cyclooxygenase2 inhibitor
Patients with acute renal failure
Patients with previous intervention related with moyamoya disease