SEVOflurane Inhalation in CARdiac Arrest Resuscitated Patients Treated With Therapeutic Hypothermia (SEVOCAR)

University Hospital, Clermont-Ferrand

Status: Completed

Conditions: Therapeutic Hypothermia; Cardiac Arrest

Treatments: Drug: sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02201134

2014-001196-31

CHU-0199

Details and patient eligibility

About

Studying the feasibility of an initial sedation with inhalated sevoflurane during therapeutic hypothermia of cardiac arrests resuscitated patients.

Full description

Prospective clinical study in ICU with ventilated patients sedated with sevoflurane using the Mirus® and Anaconda® , establishing the feasibility of an initial sedation of patients resuscitated from cardiac arrest and treated with therapeutic hypothermia.

Enrollment: 20 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• -Adult patients ventilated requiring therapeutic hypothermia in ICU
• Stable respiratory and hemodynamic conditions
• Epinephrine and norepinephrine infusion rate < 1,5 g/kg/min
• Consent of patients or family
• Arterial line
• Patients resuscitated after cardiac arrest
• No Flow < 10 min
• Low Flow < 20 min
• Neutropenia < 1 G/L
• Post traumatic cardiac arrest
• Contraindication of halogenated anesthesics
• Extra corporeal life support or intra aortic balloon pump

Exclusion criteria

• -Pregnant woman
• Hemodynamic instability
• Brain death defined by the disappearance of brain stem reflexes

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

sevoflurane

Other group

Treatment:

Drug: sevoflurane