Sevoflurane Sedation as an Alternative for Awake Fiberoptic Intubation in Difficult Airway Patients

Tanta University

Status: Enrolling

Conditions: Sedation; Sevoflurane; Difficult Airway; Awake Fiberoptic Intubation

Treatments: Drug: Sevoflurane; Drug: 2% Xylocaine (2 ml )

Study type: Interventional

Funder types: Other

Identifiers

NCT06601036

36264PR591/3/24

Details and patient eligibility

About

The aim of this study is to compare patient satisfaction and intubating conditions with fiber optic intubation under sevoflurane sedation versus airway blocks in difficult airway patients

Full description

Awake fiberoptic intubation (AFOI) is a suitable option for anticipated difficult intubation. The ideal condition for AFOI requires a calm, cooperative patient with blunted airway reflexes to facilitate easy intubation, especially if there is difficulty with laryngeal anatomy and/or pathology.

For this purpose, sedative and anxiolytic agents such as benzodiazepines, sevoflurane, remifentanil, ketamine, propofol, and dexmedetomidine are almost always required to relieve the patients from comfort without impairing ventilation. Patient responsiveness and cooperation are almost always required.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 50 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-II.
• Patients with difficult airway (Mallampati grade 3 and 4 with mouth opening less than 5 cm).

Exclusion criteria

• Patient refusal.
• Patients with bleeding disorders and nasal mass.
• Allergy or intolerance to one of the study medications.
• Patients with uncontrolled systemic diseases.
• patients with gastro-esophageal reflex.
• history of nasopharyngeal surgery or drug abuse.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

70 participants in 2 patient groups

Sevoflurane sedation group

Experimental group

Description:

Patients will undergo fiberoptic intubation under sevoflurane sedation.

Treatment:

Drug: Sevoflurane

Awake fiberoptic group

Active Comparator group

Description:

Patients will undergo fiberoptic intubation with bilateral Superior Laryngeal Nerve block and Recurrent laryngeal nerve block.

Treatment:

Drug: 2% Xylocaine (2 ml )