Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

Seoul National University

Status: Completed

Conditions: Catheter Site Discomfort; Urinary Bladder Neoplasms; Complications; Anesthesia

Treatments: Drug: Desflurane; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02096224

CRBDSevoDes

Details and patient eligibility

About

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Full description

The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The volatile anesthetics such as sevoflurane and desflurane are known to block the muscarinic receptor in different ways.

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Enrollment: 108 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for transurethral bladder excision under general anesthesia
• ASA I-III

Exclusion criteria

• Bladder outflow obstruction
• Overactive bladder
• End-stage renal disease
• Neurogenic bladder
• Heart failure
• Arrhythmia
• Morbid obesity
• Use of chronic analgesic medication
• Hepatic disease
• Pulmonary disease
• Psychiatric disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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108 participants in 2 patient groups

Sevoflurane

Experimental group

Description:

Sevoflurane will be administered as the maintenance agent of general anesthesia.

Treatment:

Drug: Sevoflurane

Desflurane

Active Comparator group

Description:

Desflurane will be administered as the maintenance agent of general anesthesia.

Treatment:

Drug: Desflurane