Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations - 11

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The University of Chicago

Status

Completed

Conditions

Opioid-Related Disorders
Substance-Related Disorders

Treatments

Drug: 0.6% Sevoflurane
Drug: 0.3 % Sevoflurane
Drug: 30% Nitrous oxide
Drug: 15 % Nitrous oxide
Other: Placebo

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT00000259
R01DA008391 (U.S. NIH Grant/Contract)
R01-08391-11
NIDA-08391-11

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.

Enrollment

12 patients

Sex

All

Ages

21 to 39 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

12 participants in 5 patient groups, including a placebo group

Placebo
Placebo Comparator group
Description:
Subject inhales no drug (100% oxygen)
Treatment:
Other: Placebo
0.3% sevoflurane
Active Comparator group
Treatment:
Drug: 0.3 % Sevoflurane
0.6% sevoflurane
Active Comparator group
Treatment:
Drug: 0.6% Sevoflurane
15% Nitrous oxide
Active Comparator group
Treatment:
Drug: 15 % Nitrous oxide
30% Nitrous oxide
Active Comparator group
Treatment:
Drug: 30% Nitrous oxide

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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