Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations - 11

The University of Chicago

Status: Completed

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Drug: 0.6% Sevoflurane; Drug: 0.3 % Sevoflurane; Drug: 30% Nitrous oxide; Drug: 15 % Nitrous oxide; Other: Placebo

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000259

R01DA008391 (U.S. NIH Grant/Contract)

R01-08391-11

NIDA-08391-11

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.

Enrollment: 12 patients

Sex: All

Ages: 21 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

12 participants in 5 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Subject inhales no drug (100% oxygen)

Treatment:

Other: Placebo

0.3% sevoflurane

Active Comparator group

Treatment:

Drug: 0.3 % Sevoflurane

0.6% sevoflurane

Active Comparator group

Treatment:

Drug: 0.6% Sevoflurane

15% Nitrous oxide

Active Comparator group

Treatment:

Drug: 15 % Nitrous oxide

30% Nitrous oxide

Active Comparator group

Treatment:

Drug: 30% Nitrous oxide