Sex Difference Effects on Postoperative Sleep, Inflammation and Cognition in Patients Undergoing General Anesthesia

China Medical University

Status

Unknown

Conditions

Postoperative Pain

Inflammation Function

Sex Differences

Postoperative Cognitive Function

Postoperative Sleep Quality

Treatments

Other: Video-Assisted Thoracoscopic Surgery

Study type

Observational

Funder types

Other

Identifiers

NCT05059548

Sex, cognition, inflammation

Details and patient eligibility

About

Video-Assisted Thoracoscopic Surgery(VATS) is among the most common and disabling persistent pain and inflammation conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men. And sleep disruption also remains a challenging problem in surgical settings. Postoperative sleep disturbances (POSD) are defined as changes in the sleep structure and quality of patients during the early stages after surgery, which are manifested as significantly shortened rapid eye movement (REM) sleep, prolonged awake time, and sleep fragmentation. Long-term POSD may increase the risk of postoperative delirium or cognitive dysfunction and delay recovery, thereby worsening the patient's physical condition. The aim of the study was to investigate the effect of sex differences on postoperative pain, inflammation, sleep quality and cognitive function among patients who have undergone video-assisted thoracoscopic surgery under general anesthesia.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

18-75 years old
ASA I-III
under general anesthesia

Exclusion criteria

patients with central nervous system and mental diseases;
patients with preoperative sleep disturbances;
patients with a history of sedative, analgesic, or antidepression drug use;
patients with sleep apnea or moderate and severe obstructive sleep apneahypopnea syndrome;