Sex Difference of Coronary Microvascular Dysfunction in Patients with Non-obstructive Coronary Artery Disease

Korea University

Status: Enrolling

Conditions: Microvascular Angina

Treatments: Diagnostic Test: Adenosine stress echocardiography

Study type: Observational

Funder types: Other

Identifiers

NCT06076551

2017AN0358

Details and patient eligibility

About

Sex difference of coronary microvascular dysfunction evaluated by coronary flow reserve will be assessed in patients with non-obstructive coronary artery disease

Full description

The investigators will select consecutive patients who experienced chest pain but had no significant coronary artery stenosis (<50% stenosis). Coronary microvascular function will be evaluated by adenosine stress echocardiography. Coronary blood flow velocities will be measured at 1, 2, and 3 min after adenosine infusion.

Sex difference of coronary microvascular dysfunction evaluated by coronary flow reserve will be assessed.

Enrollment: 300 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Typical/atypical chest pain or ischemic symptoms including dyspnea
• No significant coronary artery stenosis (<50% stenosis) in coronary angiography or computed tomography

Exclusion criteria

• ≥ Moderate valvular heart disease
• Congenital heart disease
• Chronic renal failure (estimated glomerular filtration rate <30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
• Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
• Receiving anticancer drugs
• Vasculitis associated with autoimmune diseases
• Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients