Sex Differences in Gene Expression in Human Adipose Tissue

University of California San Diego

Status: Completed

Conditions: Healthy; Obesity

Treatments: Radiation: CT Scan; Radiation: DEXA; Procedure: Adipose Biopsy; Procedure: Blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT00677651

070668

Details and patient eligibility

About

This project was created to assess sex differences in adipose tissue gene expression in different locations in the body. The primary objectives are to understand:

1. The mechanisms of differential body fat distribution in men and women
2. How body fat distribution is affected by reproductive hormones
3. The mechanisms linking fat distribution to health risks such as diabetes

Enrollment: 10 estimated patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Caucasian men and women 20-35 years of age
• Lean (BMI less than 25)
• Obese (BMI 30-35)

Exclusion criteria

• Hormonal birth control
• Pregnancy
• Smokers
• History of diabetes, kidney, liver or thyroid disease
• History of cancer

Trial design

10 participants in 2 patient groups

1

Description:

Five caucasian women

Treatment:

Procedure: Adipose Biopsy

Radiation: CT Scan

Procedure: Blood sample

Radiation: DEXA

2

Description:

Five caucasian men

Treatment:

Procedure: Adipose Biopsy

Radiation: CT Scan

Procedure: Blood sample

Radiation: DEXA