Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease

University of Pennsylvania

Status: Completed

Conditions: Vaso-occlusive Crisis; Sickle Cell Disease

Study type: Observational

Funder types: Other

Identifiers

NCT06345638

854343

Details and patient eligibility

About

This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (VOC) occurring among individuals with sickle cell disease (SCD).

• The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD.
• The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC.
• The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood.

Enrollment: 52 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult males and females aged 18-45
• Diagnosis of sickle cell disease
• current hospitalization for vaso-occlusive pain episode or current outpatient infusion at the recruiting sites
• Able to read and understand English
• Willing to comply with study procedures

Exclusion criteria

• Currently pregnant, pregnant within the last month, or seeking to become pregnant

Trial design

52 participants in 2 patient groups

Females with SCD

Males with SCD