Sex-Informed Data in the COVID-19 Pandemic. (G-COV)

University of Roma La Sapienza

Status: Unknown

Conditions: Covid19

Study type: Observational

Funder types: Other

Identifiers

NCT04497402

SAPIENZAGENDERCOVID

Details and patient eligibility

About

Sex and gender matter to health equity, especially in a pandemic. Sex (a biological attribute) and gender (a social construct) may influence an individual's susceptibility, vulnerability and exposure to infectious disease. In previous coronavirus epidemics (SARS and MERS), male sex was associated with worse outcomes. Both immune and the hemostatic response display ample sexual dimorphism.

The primary aim of the study is to determine whether sex differences in biomarkers of platelet and immune function, gut microbiome, clinical characteristics, therapy, clinical cost sensitive outcomes (i.e. in-hospital transition of care, case severity, and mortality due to COVID-19) exist in patients affected by COVID-19.

Enrollment: 88 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with laboratory confirmed SARS-Cov-2 infection of any severity.

Exclusion criteria

• Pregnancy.
• Younger than 18 years of age.

Trial design

88 participants in 4 patient groups

female COVID19 patients

Description:

Females with COVID19 disease

male COVID19 patients

Description:

Males with COVID19 disease

female matched COVID19-free patients

Description:

Free from disease COVID19 Females matched.

male matched COVID19-free patients

Description:

Free from disease COVID19 males matched.