Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

University of Missouri (MU)

Status and phase: Completed; Early Phase 1

Conditions: Vasodilation; Hypoxia

Treatments: Drug: Propranolol Pill; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT05256069

2087402

Details and patient eligibility

About

The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.

Enrollment: 31 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy adult men and women;
• 18-45 years of age;
• BMI 18-30 kg/m2;
• non-pregnant/non-breastfeeding;
• non-nicotine users;

Exclusion criteria

• Pregnancy, breastfeeding, hormonal contraceptives
• Diagnosed sleep apnea
• Current smoking/Nicotine use/drug use
• Nerve/neurologic disease
• Cardiovascular, hepatic, renal, respiratory disease
• Blood pressure ≥140/90 mmHg
• Diabetes, Polycystic ovarian syndrome
• Communication barriers
• Prescription medications
• Recent COVID-19 diagnosis with symptoms

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

31 participants in 1 patient group

Hypoxia Exposure

Experimental group

Description:

Men and women will be exposed to isocapnic hypoxia. Participants will wear a mask and systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.

Treatment:

Drug: Placebo

Drug: Propranolol Pill