Sexual Function and Quality of Life Among Patients Suffering From Inflammatory Bowel Disease(Inactive Stage)

Assiut University

Status: Completed

Conditions: Inflammatory Bowel Diseases; Sexual Function Disturbances

Treatments: Other: • Quality of life assessment; Other: Assessment of depression and anxiety; Other: The Arabic version of The International Index of Erectile Function (IIEF-5); Other: The Fatigue assessment scale (16); Other: The Female Sexual Function Index (FSFI); Other: The Sexual Quality of Life Questionnaire Male/Female (SQoL M/F)

Study type: Observational

Funder types: Other

Identifiers

NCT05707429

assiut IBD

Details and patient eligibility

About

Sexual dysfunction [SD] is a significant health burden characterized by a disturbance in sexual desire and psychophysiological changes in the sexual response cycle, resulting in marked distress and interpersonal difficulty (4). As known, both SD and depression are interrelated, so, depression may be an important determinant of sexual functioning in patients with IBD(5).

Full description

Inflammatory Bowel Diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), are characterized by a chronically relapsing course (1).

IBD is likely to have a substantial impact on body image, intimacy and sexuality, Because of symptoms like abdominal pain, fatigue, bloating, gas, and diarrhea (2).

Complications may include perianal disease, fistulae and abscesses. Surgery is frequently necessary, sometimes including the placement of a stoma or pouch. Furthermore, mood disorders, mainly depression, are reported to be common in IBD (3) .

Sexual dysfunction [SD] is a significant health burden characterized by a disturbance in sexual desire and psychophysiological changes in the sexual response cycle, resulting in marked distress and interpersonal difficulty (4). As known, both SD and depression are interrelated, so, depression may be an important determinant of sexual functioning in patients with IBD(5).

For female IBD patients, SD mainly manifests as decreased sexual desire, orgasm, and sexual arousal disorder, while for men, the most common symptom is erectile dysfunction (ED) (6).

Friedman and Knowles et al. reported that the prevalence of SD in male and female IBD patients ranged from 44% to 53.9% and 40% to 66%, respectively (7).

However, SD in IBD patients still has not attracted widespread attention, and relevant research studies are scarce.

The current study aims to assess sexual functions in patients with inactive IBD and its associated factors with sociodemographic and clinical characteristics.

assessment sexual function among inflammatory bowel disease during disease inactivity

it will evaluate the predictors and impact of SD on quality of life among those patients

Enrollment: 80 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-50 years old.
• Both sexes
• A stable sexual partner for ≥3 months
• ability to fill in and understand the questionnaire
• sign informed consent and participate voluntarily. For control group: An age-matched control group of healthy men and women, in the same region will also be invited to participate. The controls will eligible if they are 18-50 years of age, have a stable heterosexual relationship for at least 3 months and do not have bowel like IBD or irritable bowel syndrome or psychiatric problems.

Exclusion criteria

• Those who couldn't understand or fill out the questionnaire themselves and/or those with mental disorders
• Diagnosis of SD before an IBD diagnosis
• SD compounded by other diseases: cardiovascular and cerebrovascular diseases, lung diseases, liver and kidney dysfunction, diabetic neuropathy, other psychiatric disorders (e.g. depression), and neoplastic diseases, etc.
• History or current use of psychotropic drugs or medications have sexual side effects.

Trial design

80 participants in 2 patient groups

Healthy control group

Description:

will include patient's relatives or volunteers, who accept to participate in the study through invitation or posters which send or spread it to all staff hospitals about importance of the study.

Treatment:

Other: The Sexual Quality of Life Questionnaire Male/Female (SQoL M/F)

Other: The Female Sexual Function Index (FSFI)

Other: Assessment of depression and anxiety

Other: • Quality of life assessment

Other: The Arabic version of The International Index of Erectile Function (IIEF-5)

Other: The Fatigue assessment scale (16)

IBD patients inactive group

Description:

IBD patients group: they will be recruited from outpatient clinic and inpatient with CD or UC at the Gastroenterology department at Alrajhi hospital. CD patients will be assessed by the Crohn's Disease Activity Index a score of less than 150 corresponds to relative disease quiescence (remission); 150 to 219, mildly active disease; 220 to 450, moderately active disease; and greater than 450, severe disease (9).

Treatment:

Other: The Sexual Quality of Life Questionnaire Male/Female (SQoL M/F)

Other: The Female Sexual Function Index (FSFI)

Other: Assessment of depression and anxiety

Other: • Quality of life assessment

Other: The Arabic version of The International Index of Erectile Function (IIEF-5)

Other: The Fatigue assessment scale (16)