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sFlt1: a Biomarker of Organ Dysfunction in Critically-ill Patients With COVID-19? (COVIDsFlt1)

C

CHU de Reims

Status

Completed

Conditions

CORONAVIRUS INFECTIONS

Treatments

Other: measurement of circulating sFlt1 concentration

Study type

Observational

Funder types

Other

Identifiers

NCT04394195
PO20043*

Details and patient eligibility

About

Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis (Limit : 5000 characters) The management of critically-ill patients with organ failure due to COVID-19 represents a major healthcare burden. While endothelial inflammation has been reported in these patients, the pathophysiological mechanisms remain incompletely elucidated.

Full description

Extended description of the protocol, including more technical information (as compared to the Brief Summary) if desired. Do not include the entire protocol; do not duplicate information recorded in other data elements, such as eligibility criteria or outcome measures. (Limit : 32 000 characters)

The soluble fms-like tyrosine kinase 1 (SFlt1) is the soluble form of VEGF-A receptor 1 (VEGFR1). By linking VEGF-A with a high affinity, sFlt1 blocks the VEGF-A / VEFR1 axis and impairs endothelial homeostasis. Its production increases during inflammation. We hypothesize that sFlt1 is upregulated and correlates with endothelial dysfunction and outcomes in critically-ill patients with COVID-19.

Enrollment

72 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patient with documented COVID-19 (positive PCR)
  • Hospitalized in University Hospital of Reims
  • Patient or family who have previously consented

Exclusion criteria

  • Patient <18 yo
  • Patient not insured under the French social security

Trial design

72 participants in 1 patient group

patients with COVID-19 infection
Description:
patients with COVID-19 infection
Treatment:
Other: measurement of circulating sFlt1 concentration

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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